Role of Platelet-Rich Plasma (PRP) in Early Stages of Knee Osteoarthritis

Kazi Shamim Uz  Zaman; Dibakar  Sarkar; Saiful  Islam; SM Tanveer  Rahman; Syed Shahidul  Islam; Monaim  Hossen

doi:10.62848/bjpain.v2i2.3386

Authors

Kazi Shamim Uz Zaman Professor, Department of Orthopaedic, NITOR, Dhaka, Bangladesh
Dibakar Sarkar Consultant, Department of Orthopaedic, NITOR, Dhaka, Bangladesh
Saiful Islam Medical Officer, Department of Orthopaedic, NITOR, Dhaka, Bangladesh
SM Tanveer Rahman Resident, Department of Orthopaedic, NITOR, Dhaka, Bangladesh.
Syed Shahidul Islam Consultant, Evercare Hospital Ltd, Dhaka, Bangladesh.
Monaim Hossen Professor, Department of Orthopaedic, NITOR, Dhaka, Bangladesh.

DOI:

https://doi.org/10.62848/bjpain.v2i2.3386

Keywords:

Osteoarthritis (OA), Platelet-rich plasma (PRP), Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), NITOR

Abstract

Background: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. The primary objective in knee OA treatment focus on pain reduction, joint mobility improvement, as well as the reduction of disease progression and to preserve patients’ independence and quality of life. The aim of the present study was to evaluate the effectiveness of Platelet-rich plasma (PRP) for the management of early knee OA.
Methods: This experimental study was conducted in NITOR from February 2021 to June 2021. Total 30 patients were purposively selected. Pain and functional improvement were measured using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) respectively. All patients were followed up for 3 months.
Results: Almost 63% of the patients were female and their mean age was 59±7.58 years. Among them, 86.7% were in Kellgren-Lawrence grade 2. The mean duration of the disease was 16.3±9.1 months. Both VAS and WOMAC score has improved significantly in every follow up from baseline (VAS score 7.52±0.68 at baseline, 5.6±1.03 after 1 month of intervention and 4.24±1.27 after 3 months, p-value <0.05; WOMAC score 73.02±4.22 at baseline, 59.64±3.42 after 1 month of intervention and 53.26±4.65 after 3 months, p-value is <0.05).
Conclusion: Intra-articular platelet-rich plasma improves pain and function of the knee in patients with osteoarthritis.